The University of Tennessee Health Science Center’s Jonathan Wall, PhD, a professor in the Graduate School of Medicine and director of the Amyloidosis and Cancer Theranostics Program,  has  received a new three-year grant totaling $1,050,000 from the National Institutes of Health to study “Pre-targeting Immunotherapy for Light Chain (AL) Amyloidosis.” 

For this project, Wall is working to develop a novel, two-stage immunotherapy that will increase the success of currently available treatments for AL patients and possibly widen the opportunities of using such antibody-based therapies to other forms of systemic amyloid disease. His grant will assess the use of novel bifunctional “peptope,” a combination of a pan-amyloid-reactive peptide and a linear epitope sequence, that targets amyloid deposits for removal. 

“By adding this peptope we found that it attracts antibodies to sites of amyloid deposition and signals for amyloid removal to commence,” Dr. Wall said. “We anticipate that this novel, two-stage immunotherapy will enhance the effectiveness of current treatments for AL patients and potentially extend the utility of antibodies to other forms of systemic amyloid disease.”

There currently is no cure for light chain amyloidosis, and the prognosis for patients is poor with a median survival of less than three years. Using technology that Dr. Wall and his team have worked with for years, the goal of this project is to take this new peptope and combine it with antibodies that are already approved for use in industry in the hopes of it moving to clinical trials much faster.     

Wall has been with UTHSC since January 1995, and has received continual funding to study Amyloidosis for almost 10 years. The Knoxville research program has been working on Amyloidosis for over 50 years, developing new diagnostic techniques and drugs for this very rare disease.